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Symptoms include:. If CVI is not treated, the pressure and swelling increase until the tiniest blood vessels in the legs capillaries burst.

When this happens, the overlying skin takes on a reddish-brown color and is very sensitive to being broken if bumped or scratched. At the least, burst capillaries can cause local tissue inflammation and internal tissue damage.

At worst, this leads to ulcers, open sores on the skin surface. These venous stasis ulcers can be difficult to heal and can become infected. When the infection is not controlled, it can spread to surrounding tissue, a condition known as cellulitis.

CVI is often associated with varicose veins, which are twisted, enlarged veins close to the surface of the skin.

They can occur almost anywhere, but most commonly occur in the legs. Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission.

We do not endorse non-Cleveland Clinic products or services. Appointments Show More. Over time, these abnormal cells can crowd out healthy blood cells in the bone marrow, leading to fewer healthy white blood cells, red blood cells and platelets, causing the signs and symptoms of leukemia.

However, most people with known risk factors don't get leukemia. And many people with leukemia have none of these risk factors. Mayo Clinic does not endorse companies or products.

Advertising revenue supports our not-for-profit mission. This content does not have an English version. This content does not have an Arabic version.

Request an appointment. Overview Leukemia is cancer of the body's blood-forming tissues, including the bone marrow and the lymphatic system.

Request an Appointment at Mayo Clinic. Lymphatic system Open pop-up dialog box Close. Lymphatic system Your body's lymphatic system is part of your immune system, which protects you against infection and disease.

Share on: Facebook Twitter. Show references What you need to know about leukemia. National Cancer Institute. Accessed Aug. Understanding leukemia. Taking time: Support for people with cancer.

Riggin ER. Allscripts EPSi. Mayo Clinic, Rochester, Minn. July 5, Begna KH expert opinion. August 9, Related Infographic: Blood Cancer Awareness.

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Synovial sarcoma is one of the rarest types of cancer. This type of soft tissue sarcoma can arise almost anywhere in the body, including the joints.

Synovial sarcoma most commonly occurs in the extremities, particularly in the thighs, knees, feet and forearms. However, it also can occur in the head, neck and trunk.

We spoke with Dejka M. Araujo, M. Yeagley to learn more about diagnosis, treatment options and the latest research on synovial sarcoma. What are common synovial sarcoma symptoms?

At what point should someone see a doctor? Most synovial sarcoma patients discover their tumor from a lump, and for some, related pain.

Synovial sarcoma may also occur in the lungs, so see your doctor if you notice shortness of breath. There are two major types: monophasic, which is made up of only spindle cells, and biphasic, which is made up of both spindle cells and epithelial cells.

We also see it in men slightly more often than women. However, an official diagnosis can only be made by a pathologist after obtaining tissue samples through biopsy or surgery.

Do your research. If possible, see a doctor who specializes in sarcoma and works at a cancer center that has surgeons, radiation oncologists and pathologists who also specialize in sarcoma.

If the diagnosis was made after the tumor was removed, make sure the doctors got all the cancer out. At present, surgery is the most effective treatment, but radiation and chemotherapy may extend the time before recurrence and metastasis when used in conjunction with surgery.

Yes, synovial sarcoma often does spread to other parts of the body. To reach the heart, the blood needs to flow upward from the veins in the legs.

Calf muscles and the muscles in the feet need to contract with each step to squeeze the veins and push the blood upward.

To keep the blood flowing up, and not back down, the veins contain one-way valves. Chronic venous insufficiency occurs when these valves become damaged, allowing the blood to leak backward.

Valve damage may occur as the result of aging, extended sitting or standing or a combination of aging and reduced mobility.

When the veins and valves are weakened to the point where it is difficult for the blood to flow up to the heart, blood pressure in the veins stays elevated for long periods of time, leading to CVI.

CVI most commonly occurs as the result of a blood clot in the deep veins of the legs, a disease known as deep vein thrombosis DVT. CVI also results from pelvic tumors and vascular malformations, and sometimes occurs for unknown reasons.

Failure of the valves in leg veins to hold blood against gravity leads to sluggish movement of blood out of the veins, resulting in swollen legs.

Chronic venous insufficiency that develops as a result of DVT is also known as post-thrombotic syndrome. As many as 30 percent of people with DVT will develop this problem within 10 years after diagnosis.

It occurs more frequently in people over age 50, and more often in women than in men. The seriousness of CVI, along with the complexities of treatment, increase as the disease progresses.

The problem will not go away if you wait, and the earlier it is diagnosed and treated, the better your chances of preventing serious complications.

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